According to MTV, Lovato explained that despite the play on the word "heartbreak" in the title, the song is about the exact opposite.
"It's a song about showing someone you love that you're the one right in front of them.
This is a song about faith." Joe De Andrea of Absolute Punk praised "Mistake" and "Give Your Heart a Break" as ballads going "far and beyond anything in Lovato's prior arsenal.
It was released on January 23, 2012 by Hollywood Records, as the second and final single from the album.
The song was written and produced by Josh Alexander and Billy Steinberg.
"Give Your Heart a Break" incorporates drums, violin and strings.
The latter two, according to music critics, are reminiscent of those used in Coldplay's "Viva la Vida".
In Belgium (Ultratop 50 Flanders), the song peaked at number 32, her first appearance and highest position on the chart and spent nine weeks on the chart.
In New Zealand, the song debuted at number 33, her third song to chart on the top 40 and has so far peaked at number 9, marking the first time Lovato had two Top 10 singles from one album in the country.
In April 2014, the song was certified three-times platinum by the RIAA; as of October 2014, it has sold 2.1 million digital copies. According to Lovato about "the new music video, i'm basically trying to convince a guy that i didn't break his heart, and we get into a fight and i try to win him over again" and "So I do something special for him at the end of the song".
The music video for "Give Your Heart a Break" was filmed in late February 2012 and was directed by Justin Francis. The music video begins with Lovato and her boyfriend (portrayed by Alex Bechet) having an argument over the phone.
Originally, it was announced the second single from the album "Who's That Boy" (featuring Dev), but later was scrapped due to Dev's pregnancy.